Prof. Wang Jingfei at the Harbin Veterinary Research Institute of CAAS published a research article titled "High-resolution structure analysis reveals the invasion and assembly process of alpha viruses to host cells" in Nature Communications. The study analyzed a 3.5 Å cryo-electron microscopy (cryo-EM) structure of a Sindbis virus strain, which is of great importance to characterizing the pH-driven conformational changes of virion and also provides structural insights into the design of drugs and vaccines for alpha viruses.

Overall cryo-EM structure of SINV Location of the newly-identified pocket factor (A) and the local enlarged view (B)