The bottlenecks of creation and application of key products for ATAs were broken through by Prof. Wang Jianhua’s group at Feed Research Institute of CAAS. They revealed the mechanism of antimicrobial peptides with high internalization to host cell as “close compatibility from intracellular-innate, early-defense from hypersensitive-warning” and low resistance to bacteria as “strong-penetration and multi-targets”, and established a 20 m3 scale fermentation and relative SP-nanofiltration system. The agents could significantly reduce the amount of pathogens, such asStaphylococcus aureus, and relieve the symptoms in cow mastitis.

Large-scale trial manufacture of AMPs